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Cell Stem Cell. 2010 Jul 2;7(1):5-6. doi: 10.1016/j.stem.2010.05.018. Epub 2010 Jun 17.

When fibroblasts MET iPSCs.

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1
Howard Hughes Medical Institute at Massachusetts General Hospital, Cancer Center, 185 Cambridge Street, Boston, MA 02114, USA.

Abstract

Two independent studies by Li et al. (2010) and Samavarchi-Tehrani et al. (2010) in this issue of Cell Stem Cell suggest that a mesenchymal-to-epithelial transition is a critical initiating event during the derivation of induced pluripotent stem cells (iPSCs) from fibroblasts, indicating remarkable similarities between cellular reprogramming, development, and cancer.

PMID:
20621040
DOI:
10.1016/j.stem.2010.05.018
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