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Mol Cell. 2010 Jun 25;38(6):779-80. doi: 10.1016/j.molcel.2010.06.015.

A role for SIRT1 in the hypoxic response.

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1
Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Abstract

In this issue of Molecular Cell, Lim et al. (2010) show that SIRT1 deacetylates HIF-1alpha and regulates its ability to respond to hypoxia, revealing yet another important function of SIRT1 and suggesting a connection between HIF function in aging and sirtuin enzymes.

PMID:
20620950
DOI:
10.1016/j.molcel.2010.06.015
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