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Curr Biol. 2010 Jun 22;20(12):R515-7. doi: 10.1016/j.cub.2010.05.033.

DNA replication: metazoan Sld3 steps forward.

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1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA.

Abstract

In yeast, phosphorylation of the Sld3 protein by cyclin-dependent kinases is essential for replication initiation. In metazoans, three potential Sld3 counterparts have emerged. A new study suggests that one of these, Treslin/Ticrr, is the Sld3 ortholog.

PMID:
20620904
DOI:
10.1016/j.cub.2010.05.033
[Indexed for MEDLINE]
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