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Semin Nephrol. 2010 May;30(3):216-33. doi: 10.1016/j.semnephrol.2010.03.002.

Monocyte and macrophage biology: an overview.

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Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria.


This review provides an overview of the current understanding of the biology of monocytes and macrophages. It focuses on four rapidly advancing areas that underpin recent conceptual advances, namely: (1) the bone marrow origins of monocytes and macrophages, (2) monocyte heterogeneity, (3) the early inflammatory consequences of tissue injury, and (4) current concepts of macrophage activation and their limitations.

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