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Atherosclerosis. 2010 Oct;212(2):414-7. doi: 10.1016/j.atherosclerosis.2010.06.022. Epub 2010 Jun 18.

Atherosclerosis and leukocyte-endothelial adhesive interactions are increased following acute myocardial infarction in apolipoprotein E deficient mice.

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1
University of Michigan, Department of Internal Medicine, Cardiovascular Research Center, Ann Arbor, MI 48109-0644, USA.

Abstract

OBJECTIVE:

To determine the effect of myocardial infarction (MI) on progression of atherosclerosis in apolipoprotein E deficient (ApoE-/-) mice.

METHODS AND RESULTS:

MI was induced following left anterior descending coronary artery (LAD) ligation in wild-type (WT) (n=9) and ApoE-/- (n=25) mice. Compared to sham-operated animals, MI mice demonstrated increased intravascular leukocyte rolling and firm adhesion by intravital microscopy, reflecting enhanced systemic leukocyte-endothelial interactions. To determine if MI was associated with accelerated atherogenesis, LAD ligation was performed in ApoE-/- mice. Six weeks following surgery, atherosclerosis was quantitated throughout the arterial tree by microdissection and Oil-Red-O staining. There was 1.6-fold greater atherosclerotic burden present in ApoE-/- MI mice compared to sham-operated mice.

CONCLUSIONS:

Acute MI accelerates atherogenesis in mice. These results may be related to the increased risk of recurrent ischemic coronary events following MI in humans.

[Indexed for MEDLINE]
Free PMC Article

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