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Psychiatry Res. 2010 Aug 30;183(2):170-3. doi: 10.1016/j.pscychresns.2010.04.015. Epub 2010 Jul 8.

5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder.

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Department of Psychiatry, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.


We investigated whether the promoter region of the serotonin transporter gene (5-HTTLPR) polymorphism influenced neurochemical metabolism in 26 individuals with autism spectrum disorder. Individuals with the S/S genotype of the 5-HTTLPR polymorphism showed significantly lower levels of N-acetylaspartate/creatine in the right medial prefrontal cortex compared with those with the S/L genotype.

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