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Saudi J Gastroenterol. 2010 Jul-Sep;16(3):194-7. doi: 10.4103/1319-3767.65197.

Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change.

Author information

1
Department of Drug Applied Research Center, Tabriz University of Medical Sciences, Iran.

Abstract

BACKGROUND/AIM:

Therapeutic interventions in nonalcoholic fatty liver disease are limited, while anti-oxidative materials have shown benefits in animal models. This study aimed to evaluate grape seed extract as an anti-oxidative material in this process. Therapeutic effects of grape seed extract were evaluated in comparison to vitamin C in a double-blind setting.

MATERIALS AND METHODS:

Fifteen patients were enrolled in each group. Liver function tests were done; also, grade of steatosis and pattern of echogenicity of the liver were determined. Patients were followed up by the same evaluation repeated in first, second and third months.

RESULTS:

Mean age +/- standard deviation was 43.2 +/- 10.3 years. Grape seed extract (GSE) significantly improved the grade of fatty liver change; and resulted in significant decrease in alanine aminotransferase in patients receiving the concentrate compared to those receiving vitamin C independently, from the initial grade of steatosis.

CONCLUSIONS:

This study describes the beneficial effect of using grape seed extract for three months in patients with nonalcoholic fatty liver disease. These results may improve with a longer period of follow-up.

PMID:
20616415
PMCID:
PMC3003214
DOI:
10.4103/1319-3767.65197
[Indexed for MEDLINE]
Free PMC Article

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