Format

Send to

Choose Destination
Science. 2010 Jul 9;329(5988):226-9. doi: 10.1126/science.1188954.

A molecular clock for malaria parasites.

Author information

1
Department of Biology, University of Missouri-St. Louis, One University Boulevard, St. Louis, MO 63121-4499, USA. ricklefs@umsl.edu

Abstract

The evolutionary origins of new lineages of pathogens are fundamental to understanding emerging diseases. Phylogenetic reconstruction based on DNA sequences has revealed the sister taxa of human pathogens, but the timing of host-switching events, including the human malaria pathogen Plasmodium falciparum, remains controversial. Here, we establish a rate for cytochrome b evolution in avian malaria parasites relative to its rate in birds. We found that the parasite cytochrome b gene evolves about 60% as rapidly as that of host cytochrome b, corresponding to approximately 1.2% sequence divergence per million years. This calibration puts the origin of P. falciparum at 2.5 million years ago (Ma), the initial radiation of mammalian Plasmodium at 12.8 Ma, and the contemporary global diversity of the Haemosporida across terrestrial vertebrates at 16.2 Ma.

PMID:
20616281
DOI:
10.1126/science.1188954
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center