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Bioorg Med Chem Lett. 2010 Aug 1;20(15):4712-4. doi: 10.1016/j.bmcl.2010.04.034. Epub 2010 Apr 14.

Cancer cell specific gene delivery by laminin-derived peptide AG73-labeled liposomes.

Author information

1
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Abstract

We developed laminin-derived AG73 peptide labeled liposomes for cancer specific gene therapy. AG73 peptide is well known as a ligand for syndecan-2 which is highly expressed in various cancer cells. Liposomes labeled with AG73 showed high efficient transfection efficiency in syndecan-2 overexpressing cells, and found that AG73 could be a superior molecule in the development of non-viral vector using liposomes for the gene delivery to syndecan-2 overexpressing cancer cells.

PMID:
20615691
DOI:
10.1016/j.bmcl.2010.04.034
[Indexed for MEDLINE]

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