Format

Send to

Choose Destination
J Biomed Opt. 2010 May-Jun;15(3):030513. doi: 10.1117/1.3449109.

Imaging targeted-agent binding in vivo with two probes.

Abstract

An approach to quantitatively image targeted-agent binding rate in vivo is demonstrated with dual-probe injection of both targeted and nontargeted fluorescent dyes. Images of a binding rate constant are created that reveal lower than expected uptake of epidermal growth factor in an orthotopic xenograft pancreas tumor (2.3 x 10(-5) s(-1)), as compared to the normal pancreas (3.4 x 10(-5) s(-1)). This approach allows noninvasive assessment of tumor receptor targeting in vivo to determine the expected contrast, spatial localization, and efficacy in therapeutic agent delivery.

PMID:
20614996
PMCID:
PMC2909298
DOI:
10.1117/1.3449109
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center