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Mouse kidney development.


Davidson AJ1.


StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2009 Jan 15.

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Center for Regenerative Medicine, Harvard Medical School and Harvard Stem Cell Institute, Massachusetts General Hospital, Boston, MA 02114, USA


The kidneys play a critical homeostatic role in the regulation of body fluid composition and excretion of waste products. Here I review our understanding of how the three different vertebrate kidney types (pronephros, mesonephros, and metanephros) arise during mouse development with a more comprehensive focus on the molecular regulation of metanephros formation. A detailed understanding of the genetic hierarchies governing renal development will provide insights into the pathogenesis of kidney disorders, advance efforts to direct pluripotent stem cells into therapeutically useful renal lineages in vitro, and further our understanding of renal regenerative pathways that occur in vivo.

Copyright: © 2008 Alan J. Davidson.

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