Format

Send to

Choose Destination
Clinics (Sao Paulo). 2010 Jun;65(6):629-33. doi: 10.1590/S1807-59322010000600011.

Antihyperlipidemic effect of peucedanum pastinacifolium extract in streptozotocin-induced diabetic rats.

Author information

1
Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Iran.

Abstract

INTRODUCTION:

Dyslipidemia is one of the most common complications of diabetes mellitus, significantly contributing to cardiovascular morbidity and mortality in diabetic patients. Peucedanum pastinacifolium Boiss. & Hausskn. is commonly used as an antihyperlipidemic vegetable in Iranian folk medicine.

MATERIAL AND METHODS:

In this study, we examined a hydroalcoholic extract of the aerial parts of Peucedanum pastinacifolium to determine its lipid-lowering activity in normal and streptozotocin (STZ)-induced diabetic rats. Experimental diabetes mellitus was induced by a single intraperitoneal administration of streptozotocin. Normal and streptozotocin-induced diabetic rats were separated into four groups. The groups were fed with 0, 125, 250 or 500 mg/kg body weight of Peucedanum Pastinacifolium hydroalcoholic Extract (PPE) in aqueous solution for 30 days.

RESULTS:

The results show that there were significant (P < 0.05) increases in total serum cholesterol, triglyceride and low-density lipoprotein cholesterol (LDL-C) and a decrease in high-density lipoprotein cholesterol (HDL-C) in streptozotocin-induced diabetic rats. Treatment of diabetic rats with PPE over a period of a month returned these levels close to control levels.

CONCLUSION:

These results suggest that PPE has hypolipidemic effects in streptozotocin-induced diabetic rats.

KEYWORDS:

Cholesterol; Hypercholesterolemia; Lipoproteins; P. pastinacifolium

PMID:
20613940
PMCID:
PMC2898543
DOI:
10.1590/S1807-59322010000600011
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Scientific Electronic Library Online Icon for PubMed Central
Loading ...
Support Center