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J Leukoc Biol. 2010 Dec;88(6):1145-56. doi: 10.1189/jlb.0410217. Epub 2010 Jul 7.

gp130 at the nexus of inflammation, autoimmunity, and cancer.

Author information

1
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19143, USA.

Abstract

Glycoprotein 130 (gp130) is a shared receptor utilized by several related cytokines, including IL-6, IL-11, IL-27, Leukemia Inhibitory Factor (LIF), Oncostatin M (OSM), Ciliary Neurotrophic Factor (CNTF), Cardiotrophin 1 (CT-1) and Cardiotrophin-like Cytokine (CLC). Gp130 plays critical roles during development and gp130-deficient mice are embryonically lethal. However, the best characterized facet of this receptor and its associated cytokines is the ability to promote or suppress inflammation. The aim of this review is to discuss the role of gp130 in promoting or preventing the development of autoimmunity and cancer, two processes that are associated with aberrant inflammatory responses.

PMID:
20610800
PMCID:
PMC2996896
DOI:
10.1189/jlb.0410217
[Indexed for MEDLINE]
Free PMC Article

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