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J Neurophysiol. 2010 Sep;104(3):1484-96. doi: 10.1152/jn.00187.2010. Epub 2010 Jul 7.

Predicting the timing of spikes evoked by tactile stimulation of the hand.

Author information

1
Zanvyl Krieger Mind/Brain Institute and Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

What does the hand tell the brain? Tactile stimulation of the hand evokes remarkably precise patterns of neural activity, suggesting that the timing of individual spikes may convey information. However, many aspects of the transformation of mechanical deformations of the skin into spike trains remain unknown. Here we describe an integrate-and-fire model that accurately predicts the timing of individual spikes evoked by arbitrary mechanical vibrations in three types of mechanoreceptive afferent fibers that innervate the hand. The model accounts for most known properties of the three fiber types, including rectification, frequency-sensitivity, and patterns of spike entrainment as a function of stimulus frequency. These results not only shed light on the mechanisms of mechanotransduction but can be used to provide realistic tactile feedback in upper-limb neuroprostheses.

PMID:
20610784
PMCID:
PMC2944675
DOI:
10.1152/jn.00187.2010
[Indexed for MEDLINE]
Free PMC Article
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