1. Epilepsy Behav. 2010 Nov;19(3):225-31. doi: 10.1016/j.yebeh.2010.06.003. Epub
2010 Jul 6.

PEARLS depression treatment for individuals with epilepsy: a randomized
controlled trial.

Ciechanowski P(1), Chaytor N, Miller J, Fraser R, Russo J, Unutzer J, Gilliam F.

Author information: 
(1)Department of Psychiatry and Behavioral Sciences, University of Washington,
Seattle, WA 98195-6560, USA. pavelcie@u.washington.edu

OBJECTIVE: Depression is associated with higher rates of suicide and lower levels
of functioning and quality of life in individuals with epilepsy. The objective of
this randomized controlled trial was to determine the effectiveness of PEARLS, a 
home-based program for managing depression in adult individuals with epilepsy and
clinically significant acute and chronic depression.
METHODS: Delivered by masters-level counselors, PEARLS is a collaborative care
intervention consisting of problem solving treatment, behavioral activation, and 
psychiatric consultation. Patients were randomly assigned to the PEARLS
intervention (N = 40) or usual care (N = 40), and assessed at baseline, 6 months,
and 12 months.
RESULTS: Compared with patients who received usual care, patients assigned to the
PEARLS intervention achieved lower depression severity (P<0.005) (Hopkins
Symptoms Checklist-20) and lower suicidal ideation (P = 0.025) over 12 months.
CONCLUSIONS: The PEARLS program, a community-integrated, home-based treatment for
depression, effectively reduces depressive symptoms in adults with epilepsy and
comorbid depression.

Copyright © 2010 Elsevier Inc. All rights reserved.

DOI: 10.1016/j.yebeh.2010.06.003 
PMID: 20609631  [Indexed for MEDLINE]