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Cancer Cell. 2010 Jul 13;18(1):3-4. doi: 10.1016/j.ccr.2010.06.007.

HIF-1alpha partners with FoxA2, a neuroendocrine-specific transcription factor, to promote tumorigenesis.

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School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.


In this issue of Cancer Cell, Qi et al. report a novel mechanism by which HIF-1alpha synergizes with a tissue-specific transcription factor, FoxA2, to promote a transcriptional program that supports prostate tumor formation and progression.

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