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J Hum Reprod Sci. 2010 Jan;3(1):11-4. doi: 10.4103/0974-1208.63115.

Efficacy of vitamin C and ethanolic extract of Sesamum indicum in promoting fertility in male Wistar rats.

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Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.



This study investigates the efficacy of ethanolic extract of Sesamum indicum (EES), vitamin C (VC), and EES + VC in promoting fertility and finding a possible link between their profertility effects and their antioxidant activities.


Forty adult male Wistar rats [Body weight (BW) 186.56 +/- 0.465 g] were randomly analyzed into four groups of ten rats each: Control, EES(G) (EES only), VC(G) (vitamin C only), and EES + VC(G) (EES in conjunction with vitamin C). Control was given 5 ml/kg BW/day of normal saline orally; EES(G) was administered 0.3 g/kg BW/day of EES; VC(G) was administered 15 mg/kg BW/ day of VC; while EES + VC(G) was administered both 0.3 g/kg BW/day of EES and 15 mg/kg BW/day of VC. All treatments were for 10 weeks.


Independent-sample T test was used to analyze the obtained results.


The results obtained showed that EES, VC, and more importantly EES + VC are capable of significantly increasing BW gain, seminal parameters, testosterone level, and body antioxidant activities.


These findings lead to the conclusion that EES + VC as well as ESS and VC promote fertility due to both their testosterone-increasing effects and their antioxidant effects.


Antioxidant; Sesamum indicum; fertility; sperm count; vitamin C

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