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J Antibiot (Tokyo). 2010 Aug;63(8):415-22. doi: 10.1038/ja.2010.56. Epub 2010 Jul 7.

Bioprospecting microbial natural product libraries from the marine environment for drug discovery.

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1
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.

Abstract

Marine microorganisms are fascinating resources due to their production of novel natural products with antimicrobial activities. Increases in both the number of new chemical entities found and the substantiation of indigenous marine actinobacteria present a fundamental difficulty in the future discovery of novel antimicrobials, namely dereplication of those compounds already discovered. This review will share our experience on the taxonomic-based construction of a highly diversified and low redundant marine microbial natural product library for high-throughput antibiotic screening. We anticipate that libraries such as these can drive the drug discovery process now and in the future.

PMID:
20606699
DOI:
10.1038/ja.2010.56
[Indexed for MEDLINE]
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