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Cardiology. 2010;116(3):151-6. doi: 10.1159/000318172. Epub 2010 Jul 7.

Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.

Author information

1
Department of Internal Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC. kuntai.lee@msa.hinet.net

Abstract

OBJECTIVES:

To determine the association between genetic variants on chromosome 4q25 and atrial fibrillation (AF) in a Taiwanese population.

METHODS:

We enrolled 200 patients with AF (mean age: 67 +/- 13 years) and 158 controls (mean age: 63 +/- 10 years). The genotypes of five SNPs, RS2634073, RS2200733, RS13143308, RS2220427 and RS10033464, were determined using multiplex single base extension methods.

RESULTS:

The distribution of the RS2200733 and RS10033464 genotypes did not significantly deviate from the Hardy-Weinberg equilibrium in the control group. The distribution of the RS2200733 genotypes differed significantly between the AF group and the controls (p = 0.03), whereas the distribution of the RS10033464 genotypes did not (p = 0.49). At RS2200733, patients with the CC genotype exhibited a 0.45 times higher risk of developing AF than those with the TT genotype (p = 0.02) and a recessive model was suggested (p = 0.01). After adjusting for various covariates, patients with the CC genotype remained recessively associated with a lower risk of developing AF than those with the TT genotype (odds ratio: 0.27, 95% confidence interval: 0.11-0.65; p < 0.01).

CONCLUSIONS:

In the Taiwanese, there is an association between SNP RS2200733 - but not RS10033464 - and the development of AF. Based on a recessive model of inheritance, individuals with SNP RS2200733 genotype CC are at a lesser risk of developing AF.

PMID:
20606429
DOI:
10.1159/000318172
[Indexed for MEDLINE]

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