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Cancer Lett. 2010 Nov 1;297(1):49-55. doi: 10.1016/j.canlet.2010.04.023. Epub 2010 Jun 1.

Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma.

Author information

1
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. nelson-yee@uiowa.edu

Abstract

The roles of transient receptor potential (TRP) cation channels in pancreatic tumorigenesis are essentially unknown. Here, we focus on the TRP melastatin-subfamily (TRPM) members. Expression of the thermally regulated transmembrane Ca(2+)-permeable channel TRPM8 is consistently up-regulated in human pancreatic adenocarcinoma cell lines and tissues. TRPM8-deficient pancreatic cancer cells have reduced ability of proliferation and cell cycle progression with elevated levels of cyclin-dependent kinase inhibitors. These results indicate that TRPM8 is aberrantly over-expressed in pancreatic adenocarcinoma and required for cellular proliferation, and they support further investigation of the potential of TRPM8 as a clinical biomarker and therapeutic target in pancreatic adenocarcinoma.

PMID:
20605675
PMCID:
PMC2933954
DOI:
10.1016/j.canlet.2010.04.023
[Indexed for MEDLINE]
Free PMC Article

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