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Resuscitation. 2010 Aug;81(8):1037-9. doi: 10.1016/j.resuscitation.2010.04.009. Epub 2010 Jun 1.

Intravenous fat emulsion to reverse haemodynamic instability from intentional amitriptyline overdose.

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Division of Critical Care Medicine, University of Alberta, Canada.


We report the first case of amitriptyline toxicity treated with intravenous fat emulsion (IFE). Toxicity was manifested as vasopressor-refractory haemodynamic instability despite standard therapy. Our patient recovered with no adverse effects noted.

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