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Atherosclerosis. 2010 Sep;212(1):193-6. doi: 10.1016/j.atherosclerosis.2010.05.009. Epub 2010 May 13.

Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus.

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1
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA. dov.shiffman@celera.com

Abstract

OBJECTIVE:

LPA encodes apolipoprotein(a), and a CCTC haplotype in the LPA locus is associated with CHD. The 4399Met variant (rs3798220) of LPA has a risk estimate for CHD similar to that of the CCTC haplotype. We asked whether co-incidence with the 4399Met variant explained the association of the haplotype with CHD.

METHODS:

We stratified by the 4399Met variant and another LPA SNP (rs10455872) associated with CHD and tested the association between CHD and 4 SNPs that define two haplotypes associated with CHD: CCTC and CTTG.

RESULTS:

For CCTC, in the presence of the rs3798220 risk allele the OR was 1.68 (95% CI: 1.05-2.68, P=0.03) versus 0.30 (95% CI: 0.06-1.59, P=0.16) with the non-risk allele. For CTTG, in the presence of the rs10455872 risk allele the OR was 1.57 (95% CI: 1.15-2.13, P=0.004) versus 1.04 (95% CI: 0.79-1.35, P=0.77) with the non-risk allele.

CONCLUSION:

The rs3798220 and rs10455872 SNPs explain the association of the CCTC and CTTG haplotypes with CHD.

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