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Cell. 2010 Jun 25;141(7):1108-10. doi: 10.1016/j.cell.2010.06.013.

Flipping MLL1's switch one proline at a time.

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1
Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Abstract

The MLL1 (mixed lineage leukemia 1) protein, which is often disrupted in leukemia, both activates and represses Hox genes during hematopoiesis. Now, Wang et al. (2010) demonstrate that the cyclophilin CyP33 underpins this regulatory switch by altering the state of MLL1 through cis-trans proline isomerization in the linker region between MLL1's third PHD finger and bromodomain.

PMID:
20602992
DOI:
10.1016/j.cell.2010.06.013
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