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Semin Cancer Biol. 2010 Aug;20(4):254-60. doi: 10.1016/j.semcancer.2010.06.002. Epub 2010 Jul 1.

V(D)J recombination: Born to be wild.

Author information

1
Lineberger Comprehensive Cancer Center, Department of Biochemistry and Biophysics and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. dale_ramsden@med.unc.edu

Abstract

Vertebrates employ V(D)J recombination to generate diversity for an adaptive immune response. Born of a transposon, V(D)J recombination could conceivably cause more trouble than its worth. However, of the two steps required for transposon mobility (excision and integration) this particular transposon's integration step appears mostly blocked in cells. The employment of a transposon as raw material to develop adaptive immunity was thus a less-risky choice than it might have been … but is it completely risk-free?

PMID:
20600921
PMCID:
PMC2942997
DOI:
10.1016/j.semcancer.2010.06.002
[Indexed for MEDLINE]
Free PMC Article

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