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Fitoterapia. 2010 Dec;81(8):1013-9. doi: 10.1016/j.fitote.2010.06.021. Epub 2010 Jul 1.

Knipholone anthrone from Kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells.

Author information

1
Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK. s.habtemariam@gre.ac.uk

Abstract

The present study examines the comparative cytotoxicity of knipholone (KP) and knipholone anthrone (KA) in leukaemic and melonocyte cancer cell lines. It was found that KA induces a rapid onset of cytotoxicity with IC(50) values ranging from 0.5 to 3.3 μM. In comparison to KA, KP was 70-480-times less toxic to cancer cells. Morphological and biochemical studies revealed that the cytotoxicity of KA was coupled with a quick loss of membrane integrity leading to necrotic cell death. The study identified KA as a new class of natural potential anticancer agent with a wide range of toxicological and pharmacological implications.

PMID:
20600682
DOI:
10.1016/j.fitote.2010.06.021
[Indexed for MEDLINE]

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