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Gastroenterology. 2011 Jan;140(1):199-209. doi: 10.1053/j.gastro.2010.06.047. Epub 2010 Jun 22.

Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.

Author information

1
Institute of Molecular Cancer Research, University of Zürich, Zürich, Switzerland.

Abstract

BACKGROUND & AIMS:

Chronic infection with the bacterial pathogen Helicobacter pylori causes gastric disorders, ranging from chronic gastritis to gastric adenocarcinoma. Only a subset of infected persons will develop overt disease; most remains asymptomatic despite lifelong colonization. This study aims to elucidate the differential susceptibility to H pylori that is found both across and within populations.

METHODS:

We have established a C57BL/6 mouse model of H pylori infection with a strain that is capable of delivering the virulence factor cytotoxin-associated gene A (CagA) into host cells through the activity of a Cag-pathogenicity island-encoded type IV secretion system.

RESULTS:

Mice infected at 5-6 weeks of age with CagA(+)H pylori rapidly develop gastritis, gastric atrophy, epithelial hyperplasia, and metaplasia in a type IV secretion system-dependent manner. In contrast, mice infected during the neonatal period with the same strain are protected from preneoplastic lesions. Their protection results from the development of H pylori-specific peripheral immunologic tolerance, which requires transforming growth factor-β signaling and is mediated by long-lived, inducible regulatory T cells, and which controls the local CD4(+) T-cell responses that trigger premalignant transformation. Tolerance to H pylori develops in the neonatal period because of a biased ratio of T-regulatory to T-effector cells and is favored by prolonged low-dose exposure to antigen.

CONCLUSIONS:

Using a novel CagA(+)H pylori infection model, we report here that the development of tolerance to H pylori protects from gastric cancer precursor lesions. The age at initial infection may thus account for the differential susceptibility of infected persons to H pylori-associated disease manifestations.

PMID:
20600031
PMCID:
PMC3380634
DOI:
10.1053/j.gastro.2010.06.047
[Indexed for MEDLINE]
Free PMC Article
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