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FEBS Lett. 2010 Aug 4;584(15):3250-9. doi: 10.1016/j.febslet.2010.06.035. Epub 2010 Jun 30.

Brown vs white adipocytes: the PPARgamma coregulator story.

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Department of Metabolic and Endocrine Diseases, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.


The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors. The peroxisome proliferator-activated receptor gamma (PPARgamma) is considered to be one of the master regulators of adipocyte differentiation. The presence of two functionally distinct types of adipose tissue, white and brown (WAT and BAT), requires an even more complex regulation of adipose tissue development. In this review we will focus on the role of PPARgamma coregulators in adipogenesis and especially on the role of PPARgamma coregulators in white and brown adipose tissue. Specificity in coregulator function in WAT and BAT may form an additional level of regulation of adipose tissue development.

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