Format

Send to

Choose Destination
See comment in PubMed Commons below
J Am Acad Dermatol. 2010 Oct;63(4):580-6. doi: 10.1016/j.jaad.2009.09.049.

Validation and response to treatment of a pruritus self-assessment tool in patients with moderate to severe psoriasis.

Author information

1
Tufts Medical Center, Boston, Massachusetts 02111-1533, USA. agottlieb@tuftsmedicalcenter.org

Abstract

BACKGROUND:

Pruritus is a common symptom of psoriasis. In many clinical trials of psoriasis treatments, severity of pruritus is a patient-reported outcome.

OBJECTIVE:

We sought to evaluate a patient-reported pruritus self-assessment tool using data from clinical trials of a tumor necrosis factor blocker.

METHODS:

The validity of the patient-reported 6-point pruritus assessment tool (0 = none to 5 = severe) was determined using data from a phase III trial of etanercept, a tumor necrosis factor blocker. The performance of the pruritus assessment tool was then evaluated using data from two large etanercept trials.

RESULTS:

The pruritus assessment tool was validated and deemed to have good test-retest reliability (kappa coefficient = 0.71; 95% confidence interval = 0.62-0.80) and responsiveness (standardized response mean = 1.28; effect size = 1.63, responsiveness statistic = 1.54). Improvements in pruritus scores correlated with improvements in Psoriasis Area and Severity Index after 8 weeks of etanercept therapy in two phase III trials.

LIMITATIONS:

The pruritus assessment is validated only for patients with moderate to severe plaque psoriasis, and may not be applicable to other patient populations.

CONCLUSIONS:

The pruritus assessment tool is a valid measurement of pruritus intensity in patients with moderate to severe plaque psoriasis and can discriminate between patients on and off treatment.

PMID:
20599294
DOI:
10.1016/j.jaad.2009.09.049
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center