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BMC Biol. 2010 Jun 22;8:85. doi: 10.1186/1741-7007-8-85.

The architecture of RNA polymerase fidelity.

Author information

1
Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. cdkaplan@tamu.edu

Abstract

The basis for transcriptional fidelity by RNA polymerase is not understood, but the 'trigger loop', a conserved structural element that is rearranged in the presence of correct substrate nucleotides, is thought to be critical. A study just published in BMC Biology sheds new light on the ways in which the trigger loop may promote selection of correct nucleotide triphosphate substrates. See research article http://www.biomedcentral.com/1741-7007/8/54.

PMID:
20598112
PMCID:
PMC2889878
DOI:
10.1186/1741-7007-8-85
[Indexed for MEDLINE]
Free PMC Article
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