Consumer exposure to phthalates from paper packaging: an integrated approach

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2010 Oct;27(10):1451-9. doi: 10.1080/19440049.2010.490790.

Abstract

This paper presents an integrated approach to estimate the exposure of the Portuguese population to phthalates as a contaminant originating from paperboard packaging. The approach combined data of migrant concentration in the foods resulting from a stochastic simulation with consumption data of food packaged in paperboard. The results from the exposure model were validated with experimental values actually found in the food. A short surveillance exercise was conducted with samples collection from market shelves to identify and quantify the phthalates present in both the packages and the food. The distribution of values for the di-butyl phthalate concentration in the packages was used as the input of the initial concentration in the Weibull model to estimate the concentration of this phthalate in the foods. This distribution of occurrence data was then combined with the packaging usage data in a probabilistic simulation with a Monte Carlo sampling method. Exposure values ranged between zero and 8.95 microg day(-1) kg(bw), a value close to the tolerable daily intake established by the European Food Safety Authority (EFSA)--10 microg day(-1) kg(bw). However, the 97.5th percentile and the average were 1.82 and 0.44 day(-1) kg(bw), respectively, indicating that further refinement of the estimates is not necessary. Other phthalates were also detected in the packaging samples: di-isobutyl phthalate and di-ethylhexyl phthalate. The latter was present in all packaging samples collected and was detected in a few food samples at values requiring further investigation.

MeSH terms

  • Environmental Exposure / analysis
  • Food Contamination / analysis*
  • Food Packaging / instrumentation*
  • Humans
  • Monte Carlo Method
  • Paper*
  • Phthalic Acids / adverse effects*
  • Phthalic Acids / analysis*
  • Portugal
  • Reproducibility of Results

Substances

  • Phthalic Acids