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Opt Lett. 2010 Jul 1;35(13):2121-3. doi: 10.1364/OL.35.002121.

Time-resolved diffuse optical tomography with patterned-light illumination and detection.

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Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.


This investigation explores the feasibility of performing diffuse optical tomography based on time-domain wide-field illumination and detection strategies. Wide-field patterned excitation and detection schemes are investigated in transmittance geometry with time-gated detection channels. A Monte Carlo forward model is employed to compute the time-resolved Jacobians for rigorous light propagation modeling. We demonstrate both in silico and experimentally that reconstructions of absorption structures based on wide-field patterned-light strategies are feasible and outperform classical point excitation schemes for similar data set sizes. Moreover, we demonstrate that time-domain information is retained even though large spatial areas are illuminated. The enhanced time-domain data set allows for quantitative three-dimensional imaging in thick tissue based on relatively small data sets associated with much shorter acquisition times.

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