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Vis Neurosci. 1991 Apr;6(4):399-401.

Reversal potential of GABA-induced currents in rod bipolar cells of the rat retina.

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Max-Planck-Institut für Hirnforschung, Frankfurt, Germany.


GABA-induced whole-cell currents were measured in rod bipolar cells dissociated from the adult rat retina. The patch-clamp electrode contained nystatin, which made the cell membrane electrically permeable without rupture, thus retarding the rate of diffusion of Cl- ions from the patch pipette to the cell interior. The reversal potential of the GABA-induced currents was around -70 mV at an extracellular Cl- concentration of 149 mM. We conclude that GABA generates hyperpolarizing responses in rod bipolar cells of the rat retina.

[Indexed for MEDLINE]

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