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J Rheumatol. 2010 Sep;37(9):1858-63. doi: 10.3899/jrheum.091451. Epub 2010 Jul 1.

Altered salivary redox homeostasis in patients with systemic sclerosis.

Author information

1
Centre for Neurotranslational Research, Lady Davis Institute for Medical Research, McGill University.

Abstract

OBJECTIVE:

Oxidative stress has been implicated in the pathogenesis of systemic sclerosis (SSc). Our objective was to determine whether SSc is associated with altered redox homeostasis in human saliva.

METHODS:

Study participants were 70 women with SSc and 120 female controls. 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-epi-prostaglandin F 2alpha (8-epi-PGF2alpha), and total protein carbonyls were assayed by ELISA to quantify oxidative damage to nucleic acids, lipids, and proteins, respectively, in whole nonstimulated saliva.

RESULTS:

We observed a significantly positive association between salivary log protein carbonyls and SSc in a crude statistic (OR 9.06, p < 0.0001), and multivariable model adjusted for log 8-OHdG, log 8-epi-PGF2alpha, and antioxidant exposure (OR 9.26, p < 0.0001). No significant association was noted between SSc and salivary log 8-epi-PGF2alpha or log 8-OHdG.

CONCLUSION:

Salivary redox homeostasis is perturbed in patients with SSc and may inform on the pathophysiology and presence of the disease (biomarkers) and efficacy of therapeutic interventions.

PMID:
20595279
DOI:
10.3899/jrheum.091451
[Indexed for MEDLINE]

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