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J Med Chem. 2010 Aug 12;53(15):5656-66. doi: 10.1021/jm100390h.

Heteroadamantyl cannabinoids.

Author information

1
Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.

Abstract

The aliphatic side chain plays a pivotal role in determining the cannabinergic potency of tricyclic classical cannabinoids. We have synthesized a series of analogues in which the C3 position is substituted either directly or through a one-carbon atom linker with an adamantylamine or with an oxa- or an oxazaadamantane. The oxaadamantane pharmacophore in analogue 16 showed the best binding profile for both receptors.

PMID:
20593789
PMCID:
PMC3699191
DOI:
10.1021/jm100390h
[Indexed for MEDLINE]
Free PMC Article

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