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Organogenesis. 2010 Jan-Mar;6(1):54-8.

Modeling bidirectional transcription using silkmoth chorion gene promoters.

Author information

1
Molecular Biology Laboratory, Department of Biochemistry and Molecular Biology, National and Kapodistrian University of Athens, Athens, Greece.

Abstract

Bidirectional transcription is an interesting feature of eukaryotic genomes; yet not all aspects of its mechanism are understood. Silkmoth choriogenesis is a model system for studying transcriptional regulation at the initiation level. As chorion genes comprise a large group of divergently transcribed gene pairs, we are presented with the possibility of investigating the intricacies of bidirectional transcription. Their well characterized 5' regulatory regions and expression profiles lay the foundation for investigating protein:protein and protein:DNA interactions, and RNA polymerase function during oocyte development. In this article we summarize current knowledge on chorion gene regulation and propose an approach to modeling bidirectional transcription using chorion promoters.

KEYWORDS:

Bombyx mori; RNA polymerase II; bidirectional promoters; chorion genes; transcriptional regulation

PMID:
20592866
PMCID:
PMC2861744
[Indexed for MEDLINE]
Free PMC Article
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