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Clin Pharmacol Ther. 2010 Aug;88(2):260-2. doi: 10.1038/clpt.2010.77. Epub 2010 Jun 30.

A systematic approach to preclinical and clinical safety biomarker qualification incorporating Bradford Hill's principles of causality association.

Author information

1
Drug Metabolism and Pharmacokinetics, Clinical Pharmacology Unit, AstraZeneca Research and Development, Alderley Park, UK.
PMID:
20592723
DOI:
10.1038/clpt.2010.77
[Indexed for MEDLINE]

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