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Brachytherapy. 2011 Jan-Feb;10(1):44-50. doi: 10.1016/j.brachy.2009.12.005. Epub 2010 Jul 1.

Cross-linked hyaluronan gel improves the quality of life of prostate cancer patients undergoing radiotherapy.

Author information

1
Cancer Center of Irvine, 16100 Sand Canyon Avenue, Irvine, CA 92618, USA. richardbwilder@yahoo.com

Abstract

PURPOSE:

To test the hypothesis that cross-linked hyaluronan gel (Hylaform) does not affect the quality of life (QOL) of prostate cancer patients undergoing radiotherapy.

METHODS AND MATERIALS:

Thirty-five patients with early stage prostate cancer underwent high-dose-rate brachytherapy to 2200 cGy and intensity modulated radiation therapy to 5040 cGy on a prospective study. Thirty patients received a single transperineal injection of 9-mL Hylaform between the prostate and rectum under transrectal ultrasound guidance immediately before the start of radiotherapy. Hylaform increased the separation between the prostate and rectum by 6-19 mm (median, 13 mm) at the start of radiotherapy. Five patients did not receive Hylaform and served as controls. We assessed gastrointestinal-related QOL using Expanded Prostate Cancer Index Composite Bowel Bother scores immediately before the start of and during the last week of radiotherapy.

RESULTS:

At the beginning of intensity modulated radiation therapy, daily mean rectal doses were 74±8 cGy (mean±standard deviation) and 105±25 cGy (mean±standard deviation) with vs. without Hylaform, respectively (p=0.01). Expanded Prostate Cancer Index Composite Bowel Bother scores decreased by 0±3 (mean±standard deviation) and 11±14 (mean±standard deviation) in patients who did and did not receive Hylaform, respectively (p=0.03).

CONCLUSIONS:

Hylaform increased the separation between the prostate and rectum and decreased the mean rectal dose, thereby improving the gastrointestinal-related acute QOL of prostate cancer patients undergoing radiotherapy. Patients will be followed up long term to determine if the improvement in acute QOL also translates into an improvement in late QOL.

PMID:
20591748
DOI:
10.1016/j.brachy.2009.12.005
[Indexed for MEDLINE]

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