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Bioorg Med Chem Lett. 2010 Aug 1;20(15):4406-11. doi: 10.1016/j.bmcl.2010.06.050. Epub 2010 Jun 15.

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

Author information

1
DISMA, Università degli Studi di Milano, Via Celoria 2, 20133 Milano, Italy.

Abstract

A series of oxime carbamates have been identified as potent inhibitors of fatty acid amide hydrolase (FAAH), an important regulatory enzyme of the endocannabinoid signaling system. Kinetic analysis indicates that they behave as non-competitive, reversible inhibitors, and show remarkable selectivity for FAAH over the other components of the endocannabinoid system.

PMID:
20591666
DOI:
10.1016/j.bmcl.2010.06.050
[Indexed for MEDLINE]

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