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Bioorg Med Chem Lett. 2010 Aug 1;20(15):4561-5. doi: 10.1016/j.bmcl.2010.06.014. Epub 2010 Jun 8.

Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.

Author information

1
GlaxoSmithKline, Molecular Discovery Research, Verona, Italy. Anna-Maria.M.Capelli@gsk.com

Abstract

The pharmacophore model of in house potent and selective alpha7 nAChR positive allosteric modulators is reported. The model was used to fish out commercially-available compounds from corporate 3D databases. As a result, novel alpha7 positive modulator chemotypes were identified. A rat full PK profile of a representative compound is also described.

PMID:
20591663
DOI:
10.1016/j.bmcl.2010.06.014
[Indexed for MEDLINE]

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