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BJU Int. 2010 Dec;106(11):1602-6. doi: 10.1111/j.1464-410X.2010.09440.x.

Number of prostate cancer risk alleles may identify possibly 'insignificant' disease.

Author information

1
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Abstract

OBJECTIVE:

To determine whether the cumulative effects of five prostate cancer risk alleles (three single-nucleotide polymorphisms [SNPs] on chromosome 8Q24 and two SNPs on chromosome 17a) could help to identify possibly 'insignificant' disease.

MATERIALS AND METHODS:

We genotyped 629 men of European ancestry who underwent radical prostatectomy at our institution between 2002 and 2007. Possibly 'insignificant' CaP was defined using the Ohori criteria (organ-confined, tumour volume <0.5 mL, Gleason pattern ≤4). Statistical analysis was used to compare patients with 'insignificant' and all other 'significant' cancer based upon genotype. Carrier status for the 5 SNPs were compared between patients with 'insignificant' disease and a separate population of 801 controls without CaP.

RESULTS:

Overall, 38 (6.0%) patients with CaP met the Ohori criteria for 'insignificant' disease. Men with 'significant' cancer had a greater frequency of any of the five risk alleles than either patients with 'insignificant' disease or controls. None of the individual alleles genotyped on chromosomes 8 or 17 distinguished between 'significant' and 'insignificant' CaP. However, carriers of two or more risk alleles were more likely to have 'significant' disease.

CONCLUSIONS:

Although no single risk allele distinguished 'insignificant' CaP, 'insignificant' disease was nearly three times as likely among carriers of ≤ one risk allele. Future studies are needed to further elucidate the cumulative relationship between CaP risk alleles and CaP aggressiveness.

PMID:
20590552
PMCID:
PMC3072834
DOI:
10.1111/j.1464-410X.2010.09440.x
[Indexed for MEDLINE]
Free PMC Article

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