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Pediatr Blood Cancer. 2010 Dec 1;55(6):1236-8. doi: 10.1002/pbc.22671.

A high circulating copy number of HHV-6 due to chromosomal integration in a child with acute lymphoblastic leukemia.

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Pediatric Research Centre, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland.


We report a case of a 3.5-year-old female with a very high copy number of human herpesvirus 6 (HHV-6) detected by PCR in blood during acute lymphoblastic leukemia induction therapy. The patient was unsuccessfully treated with antiviral drugs. HHV-6 genome was shown to be constitutively integrated into chromosome 22q-tel, likely to be inherited from the mother who was found to carry high HHV-6 copy number. This case highlights the importance of excluding HHV-6 chromosomal integration before diagnosing HHV-6 infection or reactivation in immunocompromised patients.

[Indexed for MEDLINE]

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