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AIDS. 2010 Jul 17;24(11):1778-81. doi: 10.1097/QAD.0b013e32833a2537.

Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling.

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1
Behavioral and Biomedical Research Division, Family Health International, Research Triangle Park, North Carolina 27709, USA. cmorrison@fhi.org

Abstract

Hormonal contraceptives are used widely worldwide; their effect on HIV acquisition remains unresolved. We reanalyzed data from the Hormonal Contraception and HIV Study using marginal structural modeling to reduce selection bias due to time-dependent confounding. Replicating our original analysis closely, we found that depo-medroxyprogesterone acetate (DMPA) but not combined oral contraceptive (COC) was associated with increased HIV acquisition. Also, young (18-24 years) but not older women who used DMPA and COCs were at increased HIV risk.

PMID:
20588106
PMCID:
PMC3148067
DOI:
10.1097/QAD.0b013e32833a2537
[Indexed for MEDLINE]
Free PMC Article
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