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Discov Med. 2010 Jun;9(49):560-4.

The immunogenicity of therapeutic proteins.

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Department of Pharmaceutical Sciences and Department of Innovation Studies, Utrecht University, Rotterdam, Netherlands.


Nearly all therapeutic proteins induce antibodies in patients. However this immunogenicity has been neglected in the use of these products, even though the antibodies may have severe consequences. During the last few years, progress has been made in understanding why patients do not tolerate these protein therapeutic products and also how to manage the problem of immunogenicity.

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