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Crit Care. 2010;14(3):171. doi: 10.1186/cc9041. Epub 2010 Jun 25.

Think (Gram) negative!

Author information

1
Infection Control Program, University of Geneva Hospitals and Medical School, CH-1211 Geneva 14, Switzerland. benedikt.huttner@hcuge.ch

Abstract

The increasing prevalence of multiresistant Gram-negative bacteria of the Enterobacteriaceae family in Europe is a worrisome phenomenon. Extended spectrum betalactamase-producing Escherichia coli strains are widespread in the community and are frequently imported into the hospital. Of even more concern is the spread of carbapenem-resistant strains of Klebsiella spp. from regions where they are already endemic. Antibiotic use is a main driver of antibiotic resistance, which again increases broad spectrum antibiotic use, resulting in a vicious circle that is difficult to interrupt. The present commentary highlights important findings of a surveillance study of antimicrobial use and resistance in German ICUs over 8 years with a focus on Gram-negative resistance.

PMID:
20587087
PMCID:
PMC2911742
DOI:
10.1186/cc9041
[Indexed for MEDLINE]
Free PMC Article

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