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Commun Integr Biol. 2010 Mar;3(2):89-94.

The F-BAR protein family Actin' on the membrane.

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Institut für Neurobiologie; Wilhelms-University; Münster; Münster, Germany.


A tight spatio-temporal coordination of the machineries controlling actin dynamics and membrane remodelling is crucial for a huge variety of cellular processes that shape cells into a multicellular organism. Dynamic membrane remodelling is achieved by a functional relationship between proteins that control plasma membrane curvature, membrane fission and nucleation of new actin filaments. The BAR/F-BAR-domain-containing proteins are prime candidates to couple plasma membrane curvature and actin dynamics in different morphogenetic processes. Here, we discuss recent findings on the membrane-shaping proteins of the F-BAR domain subfamily and how they regulate morphogenetic processes in vivo.


Cip4; F-BAR; Toca-1; WASP; WAVE; actin dynamics; cell polarity; endocytosis; membrane deformation

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