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J Cell Biol. 2010 Jun 28;189(7):1071-3. doi: 10.1083/jcb.201006033.

Joining the interface: a site for Nmd3 association on 60S ribosome subunits.

Author information

1
Laboratoire de Biochimie des ribonucléoprotéines, Institut de recherches cliniques de Montréal, Montréal, Québec H2W 1R7, Canada. marlene.oeffinger@ircm.qc.ca

Abstract

The adaptor protein Nmd3 is required for Crm1-dependent export of large ribosomal subunits from the nucleus. In this issue, Sengupta et al. (2010. J. Cell Biol. doi:10.1083/jcb.201001124) identify a binding site for yeast Nmd3 on 60S ribosomal subunits using cryoelectron microscopy and suggest a conformational model for its release in the cytoplasm. The study provides the first detailed structural description of a ribosome biogenesis factor in complex with the large subunit.

PMID:
20584913
PMCID:
PMC2894455
DOI:
10.1083/jcb.201006033
[Indexed for MEDLINE]
Free PMC Article

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