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BMC Cancer. 2010 Jun 28;10:334. doi: 10.1186/1471-2407-10-334.

8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.

Author information

1
Department of Pharmacology & Toxicology, University of Louisville, Louisville, KY, USA.

Abstract

BACKGROUND:

Human chromosome 8q24 has been implicated in prostate tumorigenesis.

METHODS:

Consequently, we evaluated seven 8q24 sequence variants relative to prostate cancer (PCA) in a case-control study involving men of African descent. Genetic alterations were detected in germ-line DNA from 195 incident PCA cases and 531 controls using TaqMan polymerase chain reaction (PCR).

RESULTS:

Inheritance of the 8q24 rs16901979 T allele corresponded to a 2.5-fold increase in the risk of developing PCA for our test group. These findings were validated using multifactor dimensionality reduction (MDR) and permutation testing (p = 0.038). The remaining 8q24 targets were not significantly related to PCA outcomes.

CONCLUSIONS:

Although compelling evidence suggests that the 8q24 rs16901979 locus may serve as an effective PCA predictor, our findings require additional evaluation in larger studies.

PMID:
20584312
PMCID:
PMC2912864
DOI:
10.1186/1471-2407-10-334
[Indexed for MEDLINE]
Free PMC Article

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