Format

Send to

Choose Destination
J Clin Exp Neuropsychol. 2010 Dec;32(10):1095-109. doi: 10.1080/13803391003749236. Epub 2010 Jun 24.

Amyotrophic lateral sclerosis patients show executive impairments on standard neuropsychological measures and an ecologically valid motor-free test of executive functions.

Author information

1
Institute of Clinical Neurophysiology, Division of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. vita.stukovnik@kclj.si

Abstract

The study aimed to evaluate the nature and extent of executive deficits in nondemented amyotrophic lateral sclerosis (ALS) patients. A total of 22 ALS patients and 21 matched controls were compared on standard neuropsychological tests of executive functions with appropriate control for motor impairment and on an ecologically valid motor-free test of executive functions, the Medication Scheduling Task (MST). Our results show that motor dysfunction can present a significant confound when using standard neuropsychological measures; however, even when accounting for motor disabilities, ALS patients show a robust pattern of cognitive dysfunctions. Additionally, MST was shown to be a sensitive measure of cognitive impairment, providing an important insight into cognitive processes relevant for patients' daily living.

PMID:
20582796
DOI:
10.1080/13803391003749236
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center