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Nat Genet. 2010 Jul;42(7):557-8. doi: 10.1038/ng0710-557.

Limits of sequence and functional conservation.

Abstract

Sequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution in generalizing from sequence to functional conservation.

PMID:
20581875
PMCID:
PMC3143036
DOI:
10.1038/ng0710-557
[Indexed for MEDLINE]
Free PMC Article
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