Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurobiol Dis. 2010 Oct;40(1):200-6. doi: 10.1016/j.nbd.2010.05.025. Epub 2010 May 23.

Alcohol-induced neuroapoptosis in the fetal macaque brain.

Author information

1
Department of Psychiatry, Washington University, St. Louis, MO 63110-1093, USA. farbern@psychiatry.wustl.edu

Abstract

The ability of brief exposure to alcohol to cause widespread neuroapoptosis in the developing rodent brain and subsequent long-term neurocognitive deficits has been proposed as a mechanism underlying the neurobehavioral deficits seen in fetal alcohol spectrum disorder (FASD). It is unknown whether brief exposure to alcohol causes apoptosis in the fetal primate brain. Pregnant fascicularis macaques at various stages of gestation (G105 to G155) were exposed to alcohol for 8h, then the fetuses were delivered by caesarean section and their brains perfused with fixative and evaluated for apoptosis. Compared to saline control brains, the ethanol-exposed brains displayed a pattern of neuroapoptosis that was widespread and similar to that caused by alcohol in infant rodent brain. The observed increase in apoptosis was on the order of 60-fold. We propose that the apoptogenic action of alcohol could explain many of the neuropathological changes and long-term neuropsychiatric disturbances associated with human FASD.

PMID:
20580929
PMCID:
PMC2926181
DOI:
10.1016/j.nbd.2010.05.025
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center